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Info on genetics and psychopathology

This section hosts general information on genetics and psychopathology, articles for parents, families and patients.

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Recent Blog posts

The CAPICE blog hosts news and announcements, events, media and articles, mostly written by the Early Stage Researchers (ESRs).

They will pursue the publication of articles about their research during their activities carried on within this project, and this blog will act as a travelogue to disseminate the research results to a broad audience of scientists, clinicians, patients and their parents and the general public.

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In August 2018, Elis Haan and Laura Schellhas had a great opportunity to be part of the Green Man Festival in Wales, UK. One of the areas of the festival is called Einstein’s Garden, which brings scientific research closer to the public. Researchers collaborate with artists to create a playful, interactive and colorful world that illustrates research work and encourages communication between scientists and festival attendees.

Activities offered at Einstein’s garden spanned a wide range of research topics, from fortune telling molecules to build clay brains. Main activities were targeted towards children but often turned out to be a good learning experience for parents as well. The atmosphere at the festival encouraged people to relax, enjoy the music and the beautiful nature, as well as to learn something new.

At our marquee, festival attendees could play an adaption of the Game of Life, called The Choice Challenge. The game incorporated three mini-games, focussing on different stages of life, and highlighted factors which contribute to people’s health choices. In each game, participants could gain points and move along the game board.

The Choice Challenge game board

As our research focus is on health behaviors during pregnancy, we organized the first game, which was about developmental stages of offspring during pregnancy and how this could be influenced by certain behaviours, such as smoking or alcohol use. People were shown colorful illustrations of the unborn child at each trimester and asked to match items with developmental stages depicted on them (e.g. first movements, brain development, hair growth) to the pregnancy trimester. Through this game, we were able to initiate discussions about the potential effects of smoking, alcohol, and caffeine use during pregnancy on children’s development. Our aim was to increase people’s awareness about general developmental stages during pregnancy and to illustrate how the timing of consumption behaviors may differentially impact a child’s life course.

 

Mini Game 1- Prenatal life

We also had an arts and crafts table, where adults and children could build origami DNA, which gave us the opportunity to explain the role of genes in our health choices.

Overall, it was a great experience, children enjoyed the game and people expressed a lot of interest in our research as well as the overall CAPICE project. In the day to day work of a PhD student, it is easy to get lost in detail and by talking to people from the wider public and answering their questions, made us see the bigger picture and importance of our research again. We hope that we could increase people’s general research understanding, as well as awareness about their own health behaviour and health choices, specifically during pregnancy.

We are very thankful for this opportunity and hope that we can do something similar with the CAPICE team in the future.

The Tobacco and Alcohol Research Group team

 

Project objectives


1. To clarify the role of genetic and environmental factors in the occurrence, course and comorbidity of mental health symptoms across childhood and adolescence..
2. To establish the overlap in genetic risk factors with other characteristics related to childhood mental health symptoms, such as adult mental disorders, IQ and brain structure.
3. To identify genetic (inherited), epigenetic (due to chemical changes to the DNA) and transcriptomic (related to gene expression) variation associated with the occurrence, course and co-morbidity of mental health symptoms during childhood and adolescence.
4. To identify biological pathways associated with mental health symptoms and to validate potential drug targets based on these pathways.
5. To build a prediction model that identifies groups of children that are at highest risk to develop chronic symptoms and that should be targeted for more intensive prevention or treatment programmes.
6. To further develop the already successful EAGLE (EArly Genetics and Lifecourse Epidemiology) consortium into a sustainable international network of researchers in which collaboration is facilitated by data harmonization and IT solutions. This will enable joint analysis of data over cohorts..
7. To build a structure to disseminate the results to a broad audience of scientists, clinicians, patients and their parents and the general public.

These ambitious objectives can be achieved by training of the ESRs in:
- childhood and adolescent mental health symptoms and their (chronic) altereffects (as a result of a non-complete recovery from the mental disorder);
- methods to analyze twin data as well as large-scale (epi)genetic and transcriptomic data across multiple cohorts;
- d
issemination of their results also through this website and its blog.

Get in Touch!

     

Contacts:
Prof. Christel Middeldorp, project coordinator

VU University Amsterdam
Dept. of Biological Psychology
email : c.m.middeldorp(at)vu.nl

Natascha Stroo, project manager
VU University Amsterdam
Dept. of Biological Psychology
email : natascha.stroo(at)vu.nl

Matteo Mauri, web & dissemination manager
University of Cagliari
email : matteo.mauri(at)diee.unica.it

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