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Recent Blog posts

The CAPICE blog hosts news and announcements, events, media and articles, mostly written by the Early Stage Researchers (ESRs).

They will pursue the publication of articles about their research during their activities carried on within this project, and this blog will act as a travelogue to disseminate the research results to a broad audience of scientists, clinicians, patients and their parents and the general public.

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In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority.
This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a wellestablished collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems.
Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology.

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Project objectives


1. To clarify the role of genetic and environmental factors in the occurrence, course and comorbidity of mental health symptoms across childhood and adolescence..
2. To establish the overlap in genetic risk factors with other characteristics related to childhood mental health symptoms, such as adult mental disorders, IQ and brain structure.
3. To identify genetic (inherited), epigenetic (due to chemical changes to the DNA) and transcriptomic (related to gene expression) variation associated with the occurrence, course and co-morbidity of mental health symptoms during childhood and adolescence.
4. To identify biological pathways associated with mental health symptoms and to validate potential drug targets based on these pathways.
5. To build a prediction model that identifies groups of children that are at highest risk to develop chronic symptoms and that should be targeted for more intensive prevention or treatment programmes.
6. To further develop the already successful EAGLE (EArly Genetics and Lifecourse Epidemiology) consortium into a sustainable international network of researchers in which collaboration is facilitated by data harmonization and IT solutions. This will enable joint analysis of data over cohorts..
7. To build a structure to disseminate the results to a broad audience of scientists, clinicians, patients and their parents and the general public.

These ambitious objectives can be achieved by training of the ESRs in:
- childhood and adolescent mental health symptoms and their (chronic) altereffects (as a result of a non-complete recovery from the mental disorder);
- methods to analyze twin data as well as large-scale (epi)genetic and transcriptomic data across multiple cohorts;
- d
issemination of their results also through this website and its blog.

Get in Touch!

     

Contacts:
Prof. Christel Middeldorp, project coordinator

VU University Amsterdam
Dept. of Biological Psychology
email : c.m.middeldorp(at)vu.nl

Natascha Stroo, project manager
VU University Amsterdam
Dept. of Biological Psychology
email : natascha.stroo(at)vu.nl

Matteo Mauri, web & dissemination manager
University of Cagliari
email : matteo.mauri(at)diee.unica.it

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