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Info on genetics and psychopathology

This section hosts general information on genetics and psychopathology, articles for parents, families and patients.

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Recent Blog posts

The CAPICE blog hosts news and announcements, events, media and articles, mostly written by the Early Stage Researchers (ESRs).

They will pursue the publication of articles about their research during their activities carried on within this project, and this blog will act as a travelogue to disseminate the research results to a broad audience of scientists, clinicians, patients and their parents and the general public.

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This article contains the abstract of the second talk "Genomic prediction of cognitive traits in childhood and adolescence", given by Andrea Giuseppe Allegrini, ESR in the CAPICE project, at 2018 BGA annual meeting, that took place in BOSTON, Massachusetts, USA, (June 21, 2018, 14:45). Here the agenda of the event is available.

This article contains the abstract of the talk "A multi-polygenic score approach to the prediction of harmonized aggression", given by Andrea Giuseppe Allegrini, ESR in the CAPICE project, at 2018 BGA annual meeting, that took place in BOSTON, Massachusetts, USA, (June 23, 2018, 10:30). Here the agenda of the event is available.

This is Hema Sekhar Reddy Rajula, PhD student at the UNICA (University of Cagliari, Italy). For my secondment, I worked on CAPICE data catalog at Janssen-Cilag AB (Stockholm) for the duration of three months from March to May 2018. 

“Be less curious about people and more curious about ideas” - Marie Curie

“Hallo allemaal, Ik ben Kratika!”

Hello Everyone,
I am Kratika. Coming to The Netherlands has definitely been a challenge as I did not speak Dutch. But, gradually, I learnt the language and am a bit confident enough to speak. I love learning new languages and exploring cultures, by now, I have a good command over 6 languages! This country, and my university have been very supportive and accepting towards me as a foreigner.

Hej hej! I’m Sabrina Doering and I’m an early stage researcher (ESR) in the CAPICE project at the University of Gothenburg (Göteborgs Universitet). Together with Ashley Thompson and Marica Leone, I’m one of the CAPICE ESRs based in Sweden.
Living in Germany far too long, I decided to go abroad after high school and started my academic journey by studying psychology in the Netherlands. After three years of riding a bike, come rain or shine, I received my bachelor of science from Radboud Universiteit Nijmegen. To specialize in clinical psychology and neuroscience as well as to gain clinical experience, I moved to Switzerland to do a two years master of science at the University of Basel. Within CAPICE, I am lucky enough to combine my research interests along with the opportunity to be educated in the field of psychiatric genetics.

Project objectives


1. To clarify the role of genetic and environmental factors in the occurrence, course and comorbidity of mental health symptoms across childhood and adolescence..
2. To establish the overlap in genetic risk factors with other characteristics related to childhood mental health symptoms, such as adult mental disorders, IQ and brain structure.
3. To identify genetic (inherited), epigenetic (due to chemical changes to the DNA) and transcriptomic (related to gene expression) variation associated with the occurrence, course and co-morbidity of mental health symptoms during childhood and adolescence.
4. To identify biological pathways associated with mental health symptoms and to validate potential drug targets based on these pathways.
5. To build a prediction model that identifies groups of children that are at highest risk to develop chronic symptoms and that should be targeted for more intensive prevention or treatment programmes.
6. To further develop the already successful EAGLE (EArly Genetics and Lifecourse Epidemiology) consortium into a sustainable international network of researchers in which collaboration is facilitated by data harmonization and IT solutions. This will enable joint analysis of data over cohorts..
7. To build a structure to disseminate the results to a broad audience of scientists, clinicians, patients and their parents and the general public.

These ambitious objectives can be achieved by training of the ESRs in:
- childhood and adolescent mental health symptoms and their (chronic) altereffects (as a result of a non-complete recovery from the mental disorder);
- methods to analyze twin data as well as large-scale (epi)genetic and transcriptomic data across multiple cohorts;
- d
issemination of their results also through this website and its blog.

Get in Touch!

     

Contacts:
Prof. Christel Middeldorp, project coordinator

VU University Amsterdam
Dept. of Biological Psychology
email : c.m.middeldorp(at)vu.nl

Natascha Stroo, project manager
VU University Amsterdam
Dept. of Biological Psychology
email : natascha.stroo(at)vu.nl

Matteo Mauri, web & dissemination manager
University of Cagliari
email : matteo.mauri(at)diee.unica.it

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